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Familial Coaggregation of Cryptorchidism and Hypospadias.

Auteur
SCHNACK (Tine-H); POULSEN (Gry); MYRUP (Charlotte); WOHLFAHRT (Jan); MELBYE (Mads)
Collectivité auteur
Department of Epidemiology Research. Statens Serum Institute. Copenhagen. DNK
Source
EPIDEMIOLOGY, Vol 21, N° 1, 2010, pages 109-113, 29 réf.
Type de document
ARTICLE (DOCUMENT PAPIER)
Langue
Anglais
Résumé
Background : It has been suggested that cryptorchidism and hypospadias may be the result of a common pathologic pathway that causes testicular dysgenesis during fetal life. To address the potential heritability of this pathway, we specifically examined to what extent a family history of cryptorchidism increases the risk of developing hypospadias and vice versa. Methods : By using Danish health registers, we identified 27,762 boys diagnosed with cryptorchidism and 4832 boys diagnosed with hypospadias in a cohort of 1,018,517 boys born during 1977-2005. Using binomial log-linear regression, we estimated risk ratios of cryptorchidism and hypospadias in male twin pairs and first-second-and third-degree relatives with a family history of hypospadias and cryptorchidism, respectively. Results : After adjusting for birth period and personal hypospadias/cryptorchidism status, there was little evidence of increased risk of cryptorchidism given a family history of hypospadias, and vice versa. However, cryptorchidism and hypospadias was associated on an individual level. Conclusion : We found no persuasive evidence that a family history of hypospadias increases the risk of cryptorchidism and vice versa. Thus, we found no support for shared heritability of hypospadias and cryptorchidism.
Mots-clés BDSP
Epidémiologie Maladie congénitale Malformation
Mots-clés Pascal
Cryptorchidie Etude familiale Hypospadias Epidémiologie Pathologie de l'appareil génital mâle Maladie congénitale Malformation Pathologie du testicule Pathologie de l'appareil urinaire Pathologie des voies urinaires Pathologie de l'urètre
Mots-clés Pascal anglais
Cryptorchidism Family study Hypospadias Epidemiology Male genital diseases Congenital disease Malformation Testicular diseases Urinary system disease Urinary tract disease Urethral disease
Provenance

Inist-CNRS - Institut de l'Information Scientifique et Technique

Identifiant BDSP
418945
Création de la notice
2010-09-16
Dernière mise à jour
2010-09-16

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