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Calcitropic hormones and occupational lead exposure.

Auteur
KRISTAL-BONEH (E.); FROOM (P.); YERUSHALMI (N.); HARARI (G.); RIBAK (J.)
Collectivité auteur
Occupational Health and Rehabilitation Institute. Raanana. ISR
Sackler Faculty of Medicine. Tel Aviv University. Tel Aviv. ISR
Source
AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol 147, N° 5, 1998, pages 458-463, 29 réf., USA
ISSN
0002-9262
Type de document
ARTICLE
Langue
Anglais
Résumé
The authors sought to clarify in a cross-sectional study the possible associations between homeostatic regulators of calcium and occupational exposure to lead. Subjects were 146 industrial male employees, 56 with and 90 without occupational lead exposure. The main outcome measures were serum concentration of parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D (calcitriol). The median values of blood lead were 40.5 mug/dl in the exposed group and 4.0 mug/dl in the controls. There were no differences between groups in dietary history and serum calcium levels. PTH and calcitriol levels were significantly higher in the exposed than in the nonexposed subjects (42.0 ± 24.2 vs. 33.6 ± 14.9 pg/ml, p<0.05 ; and 83.8 ± 27.0 vs. 67.9 ± 17.6 pmol/liter, p<0.001, respectively). Multivariate analyses showed that after controlling for possible confounders, occupational lead exposure (no/yes) was independently associated with PTH level (pg/ml) (p=7.81,95% confidence interval (Cl) 3.7-11.5) and with calcitriol (pmol/liter) (bêta=12.3,95% Cl 3.84-20.8). It is concluded that subjects occupationally exposed to lead show a substantial compensatory increase in PTH and calcitriol activities which keep serum calcium levels within normal range. This may be of clinical significance since a sustained increase in calcitropic hormones in susceptible subjects may eventually increase the risk of bone disorders.
Mots-clés BDSP
Exposition professionnelle Plomb Calcium Epidémiologie Homme Médecine travail Toxicologie
Mots-clés Pascal
Exposition professionnelle Plomb Effet biologique Régulation adaptative Taux concentration Calcium Mesure Parathormone Calcitriol Epidémiologie Homme Médecine travail Toxicologie
Mots-clés Pascal anglais
Occupational exposure Lead Biological effect Adaptive regulation Concentration factor Calcium Measurement Parathormone Calcitriol Epidemiology Human Occupational medicine Toxicology
Provenance

Inist-CNRS - Institut de l'Information Scientifique et Technique

Identifiant BDSP
164116
Création de la notice
1998-09-11
Dernière mise à jour
1998-09-11

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